MIT 18.06 Linear Algebra, Spring 2005
Instructor: Gilbert Strang
View the complete course: http://ocw.mit.edu/18-06S05
YouTube Playlist: https://www.youtube.com/playli....st?list=PLE7DDD91010

1. The Geometry of Linear Equations

License: Creative Commons BY-NC-SA
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This video introduces the fundamentals of protein design and summarizes the trajectory of the course with a focus on (1) the foundational biochemistry that protein structure prediction and design hinge on and (2) deep learning / machine learning principles overview.

Video from the Rosetta Commons PPI Workshop (February 2025)
Video Instructor: Amrita Nallathambi (UNC Chapel Hill)

Credits:
Instructor: Amrita Nallathambi
Teaching Assistants: Yehlin Cho, Cyrus Haas, and Matthew Hvasta,
RC Leadership and NSF Sponsor Grant PIs: Julia Koehler Leman & Jeffrey Gray
RC Education Director: Ashley Vater
Videographer: Canyon Florey
Rosetta Workshop Participants

00:00 - Introduction
00:20 - Deep Learning Revolution for Proteins
01:50 - The Transformer
03:38 - AlphaFold2 Overview
06:22 - AlphaFold2 Inputs
09:48 - AlphaFold2 Outputs
13:29 - Graph Neural Networks
16:24 - ProteinMPNN Loss
17:35 - Diffusion models
18:30 - RFDiffusion
19:52 - Inputs and Outputs
20:43 - Potentials